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ResearchedVenture Capital / Life Sciences

A. Barr Dolan

Co-Founder & Managing Partner · Charter Life Sciences (formerly Charter Ventures)

Venture Capitalist / Angel InvestorSeed, Series A, Series BLife Sciences, Biotech, Medical Devices, HealthcarePalo Alto, California
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A. Barr Dolan is the Co-Founder and Managing Partner of Charter Life Sciences (formerly Charter Ventures) in Palo Alto, California, a venture capital firm that makes seed through Series B investments in early- and clinical-stage U.S. life sciences companies across biotechnology, specialty pharmaceuticals, drug delivery, medical devices, and women's health. A Silicon Valley investor with over 40 years of experience, he is notable for backing companies including CymaBay Therapeutics (acquired by Gilead for $4.3 billion), Calgene, Geron, and InterMune, and for co-founding firms such as Heska Corporation and Adeza Biomedical.

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At a glance

Title
Co-Founder & Managing Partner
Role
Venture Capitalist / Angel Investor
Firm
Charter Life Sciences (formerly Charter Ventures)
Firm Type
Venture Capital / Life Sciences
Investment Stage
Seed, Series A, Series B
Sector Focus
Life Sciences, Biotech, Medical Devices, Healthcare
Location
Palo Alto, California

Background

A. Barr Dolan is a veteran venture capitalist with over 40 years of experience investing in early-stage technology and life sciences companies in Silicon Valley. He is the Co-Founder and Managing Partner of Charter Life Sciences, a clinical-stage venture capital firm focused on early-stage life sciences opportunities. Prior to founding Charter Life Sciences, Dolan was a founding general partner of the Charter Ventures family of venture capital funds, where he served from 1982 to 2010.

Dolan holds an exceptionally strong academic background spanning science, engineering, and business. He earned a Bachelor of Arts in Chemistry and a Master of Science in Engineering from Cornell University, a Master of Arts in Applied Science from Harvard University, and a Master of Business Administration from Stanford University. This combination of deep scientific training and business acumen has informed his ability to evaluate complex life sciences and biotech investments.

Beyond his investing career, Dolan has been an active founder and board member of multiple life sciences companies. He co-founded companies in women's health, cardiac devices, veterinary products, and biologics. He has served on the boards of directors for several public and private companies, including Heska Corporation (1986-2008), Ellie Mae Inc., KFX Inc., CMD Consulting, Xlumina, and Mcure Bio. His dual experience as both operator and investor gives him a distinctive perspective on building and scaling life sciences ventures.

Investment Thesis & Focus

Dolan and Charter Life Sciences focus on clinical-stage and early-stage investments in the life sciences sector. The firm primarily targets Series B rounds in U.S.-based startups, with a particular emphasis on biotechnology, specialty pharmaceuticals, drug delivery, medical devices, and women's health. Dolan's investment approach leverages his scientific background to evaluate technically complex opportunities in therapeutics and medical technology, often backing companies from formation through clinical development and commercialization. His track record demonstrates a pattern of investing in companies that achieve public listings or strategic acquisitions by major pharmaceutical and medical device corporations.

Notable Investments

  • CymaBay Therapeutics -- Liver disease therapeutics; acquired by Gilead Sciences in February 2024 for $4.3 billion
  • Amaranth Medical -- Charter Life Sciences led the $20M Series B round (with EDBI)
  • Xlumena -- Medical devices; acquired
  • InterMune (ITMN) -- Specialty pharma company
  • Calgene -- Biotech company; IPO, then acquired by Monsanto
  • Geron (GERN) -- Biotech company focused on telomere biology
  • Tularik (TLRK) -- Biotech company
  • Advanced Polymer Systems (APPA) -- Drug delivery company
  • EOS Biotechnology -- Biotech; acquired by Protein Design Labs
  • Genelabs Technologies (GNLB) -- Biotech company
  • Valentis (VLTS) -- Biotech company
  • Penederm -- Drug delivery; acquired by Mylan Laboratories
  • Orquest -- Medical devices; acquired by Johnson & Johnson
  • EP Technologies -- Cardiac electrophysiology catheters; IPO, then acquired by Boston Scientific
  • Adeza Biomedical (ADZA) -- Women's health company (co-founded)
  • Heska Corporation (HSKA) -- Veterinary products (co-founded)
  • Univax Biologics -- Biotech; IPO, then acquired by NABI
  • Vesta -- Women's health medical devices (co-founded); acquired by Pfizer
  • Ellie Mae, Inc. -- Financial technology
  • Linear Technology Corporation -- Semiconductors / analog devices

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