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Aaron G.L. Fletcher, PhD
ResearchedLife Sciences Venture Capital

Aaron G.L. Fletcher, PhD

Founder & General Partner / Managing Director · Bios Partners, LP

Angel InvestorsSeed, Series A, Series BBiotech, Med-Tech, Digital Health, Health IT, Health & Hospital ServicesFort Worth, Texas
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At a glance

Full Name
Aaron G.L. Fletcher, PhD
Title
Founder & General Partner / Managing Director
Firm
Bios Partners, LP
Firm Type
Life Sciences Venture Capital
Other Roles
Founder & President, Bios Research, LLC; Visiting Professor, Dallas Baptist University
Investment Stage
Seed, Series A, Series B
Investment Range
$100,000 - $5,000,000 (sweet spot ~$1,500,000)
Sector Focus
Biotech, Med-Tech, Digital Health, Health IT, Health & Hospital Services
Location
Fort Worth, Texas
AUM
$300M+ (Bios Partners)
Portfolio Size
17 companies (as of 2024)
Portfolio IPOs
7
Portfolio Acquisitions
2

Background

Aaron G.L. Fletcher, PhD, is the Founder and General Partner of Bios Partners, a Fort Worth, Texas-based life sciences venture capital firm he established in 2014. Bios Partners manages over $300 million in assets and focuses on advancing biotech innovation, particularly in underserved U.S. markets. Dr. Fletcher also founded Bios Research, LLC in 2012, a financial services firm that provides fundamental public equity research in the healthcare space, serving institutional investors and large family offices with deep analysis of biotech and med-tech sub-sectors.

Dr. Fletcher holds a Bachelor of Science in Biology from York College and a PhD in Biochemistry from Colorado State University. He has served as a visiting professor at Dallas Baptist University since 2008, where he teaches courses in Biochemistry, Bioethics, and Cell Biology. His academic grounding in the life sciences, combined with more than a decade of independent consulting in the biotech and healthcare equity industry, gives him a distinctive ability to evaluate both the scientific merit and commercial viability of therapeutic and diagnostic innovations.

Beyond his roles at Bios Partners and Bios Research, Dr. Fletcher holds several prominent board positions. He has served as Chairman of Actuate Therapeutics since 2015, as an Independent Director and Chair of the Compensation Committee at Cognition Therapeutics (NASDAQ: CGTX) since 2015, and as a Director of ONL Therapeutics since 2024. Through Bios-affiliated funds, he maintains significant personal stakes in his portfolio companies, including approximately 9.77% beneficial ownership in Cognition Therapeutics.

Investment Thesis & Focus

Bios Partners concentrates on early-stage and growth-stage investments in life sciences companies developing breakthrough therapies and medical technologies. The firm targets Seed through Series B rounds, typically investing between $100K and $5M per deal, with a sweet spot around $1.5M. Dr. Fletcher's approach is informed by Bios Research's deep fundamental analysis of the healthcare industry, which provides a proprietary lens for assessing commercial viability and market potential. The firm has a particular emphasis on biotech innovation in underserved U.S. markets and covers a broad range of therapeutic areas including oncology, neuroscience, ophthalmology, dermatology, and rare diseases. Geographic focus tends toward Texas and the broader U.S. market.

Notable Investments

  • Actuate Therapeutics -- Clinical-stage oncology company; listed on NASDAQ (Dr. Fletcher serves as Chairman since 2015)
  • Cognition Therapeutics (NASDAQ: CGTX) -- Clinical-stage biotech developing treatments for neurodegenerative diseases (Director since 2015; ~9.77% beneficial ownership)
  • ONL Therapeutics -- Retinal disease neuroprotection therapeutics; closed $65M oversubscribed Series D in September 2024 (Director since 2024)
  • Opus Genetics -- Gene therapy company; listed on NASDAQ in October 2024
  • Lantern Pharma (NASDAQ: LNTH) -- AI-driven precision oncology therapeutics
  • IN8Bio (NASDAQ: INAB) -- Clinical-stage immune-oncology cell therapy company
  • Immusoft Corporation -- Clinical-stage B cell gene therapy for rare genetic diseases
  • Azitra -- Clinical-stage microbiome-based dermatology therapeutics
  • Trefoil Therapeutics -- Engineered biologics for corneal diseases
  • 410 Medical -- Medical device company
  • Lung Therapeutics -- Pulmonary disease therapeutics

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