
Alex Shortle
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- Full Name
- Alex Shortle
- Title
- Co-founder — EO Advisors; Co-founder / Principal — Meridian Street Capital
- Firm
- EO Advisors (M&A / capital advisory); Meridian Street Capital (venture capital)
- Firm Type
- Angel / early-stage venture investor (via Meridian Street Capital)
- Investment Stage
- Seed and Series A
- Check Size
- ~$250K–$2.5M (Meridian Street Capital sweet spot ≈ $1.5M)
- Target Company Profile
- Early-stage founders (often backed "from day one") building at the intersection of healthcare and technology, including "patient-as-consumer" opportunities
- Sector Focus
- Digital health, healthcare technology, and healthcare-adjacent B2B software
- Geographic Focus
- United States (with Midwest roots)
- Location
- Zionsville / Carmel, Indiana area (Indianapolis metro)
Background
Alex Shortle began his career in New York with the leveraged and acquisition finance group of HSBC Securities, where he worked on structuring large leveraged acquisitions. He earned his undergraduate degree at Indiana University Bloomington. After HSBC, he returned to the Midwest and joined Periculum Capital Company — the Indianapolis investment bank co-founded by Robert (Bob) H. Shortle — starting as an Associate and rising to Vice President, where he focused on middle-market and lower-middle-market M&A advisory, private placements, and turnaround engagements, often serving technology companies.
Shortle went on to co-found Meridian Street Capital, a Carmel, Indiana–based venture capital firm (founded ~2015) that invests at the intersection of healthcare and technology. His primary mandate there centered on Seed and Series A investments in U.S. healthcare-technology companies, frequently supporting founders from inception. The firm positions itself as a concentrated, high-conviction partner to founders rather than a broad-portfolio fund.
More recently, Shortle co-founded EO Advisors, an investment bank offering M&A, capital formation, and strategic advisory services to growth-stage and lower-middle-market companies across multiple industry verticals. This blends his operating experience in both venture investing and traditional investment banking. He lives in Zionsville, Indiana, with his wife Annie and their three children, and lists skiing and gardening among his interests.
Investment Thesis & Focus
- Invests at "the intersection of healthcare and technology," describing the firm as a "steadfast partner to a concentrated group" of founders, "often from day one."
- Stage: Seed and Series A; check sizes roughly $250K to $2.5M, with a typical target around $1.5M.
- Sectors: digital health, health-tech, medical software/services, and healthcare-adjacent B2B SaaS; his personal focus has included "patient-as-consumer" healthcare businesses.
- Conviction-driven and concentrated rather than spray-and-pray — Meridian emphasizes deep, hands-on support for a limited number of portfolio companies.
- Brings an M&A / capital-markets lens (HSBC, Periculum, EO Advisors) to how companies build toward growth inflection points and eventual exits.
Notable Investments
- Included Health — digital health navigation platform; a notable Meridian exit.
- Hint Health — direct-primary-care membership infrastructure; realized/exit.
- First Dollar — health-savings/benefits wallet platform; exit.
- Valify — healthcare purchased-services spend management; exit.
- Rula — mental / behavioral health provider network.
- NoCD — teletherapy platform for OCD treatment.
- 1upHealth — FHIR-based health data interoperability platform.
- ClosedLoop.ai — healthcare AI / predictive analytics.
- Quilt Health — Meridian's latest disclosed investment (Seed, June 2025).
- Andros, Isaac Health, Local Infusion, Saferide Health, Imvaria, Loula, Prava Therapy — additional active healthcare-technology portfolio companies.
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