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Daniela Couto

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At a glance

Full Name
Daniela S. Couto, PhD
Title
General Partner (listed as "Principal" in older aggregator records; the firm, LinkedIn, and current investor databases now list her as General Partner)
Firm
BioGeneration Ventures (BGV)
Firm Type
Early-stage life sciences / biotech venture capital fund
Investment Stage
Seed and Series A
Check Size
~€100K–€1M, with a sweet spot around €500K (BGV deploys larger amounts across a company's life via follow-on)
Target Company Profile
Early-stage European biotech and life-science companies with demonstrable proof of concept and strong scientific founding teams; BGV frequently co-creates and incubates companies from academic IP
Sector Focus
Biotech, pharmaceuticals, and therapeutics — oncology, CNS, rare diseases, metabolic and autoimmune diseases, and ophthalmology; also digital and consumer health
Geographic Focus
Pan-European (with select North American exposure)
Location
Naarden / Amsterdam area, The Netherlands

Background

Daniela Couto is a PhD-trained biomedical engineer with more than a decade of experience in venture capital and in building early-stage biotechnology companies. She joined BioGeneration Ventures (BGV) in 2015 and has risen to General Partner, where she focuses on scientific evaluation and due diligence and on co-creating new companies from academic research. BGV is a leading pan-European early-stage life sciences fund headquartered in Naarden, The Netherlands, managing over €400 million across five funds.

Before and alongside her investing career, Couto has been an operator. From 2015 to 2018 she served as managing director of BGV portfolio company Staten Biotechnology, where she led company strategy including the research collaboration with argenX and the partnership and buy-out option with Novo Nordisk — a deal reported at roughly $485 million in value at the pre-clinical stage. Earlier, she co-founded and served as CEO of Cell2B, a cell-therapy company built on IP and technology from Prof. Sangeeta Bhatia's lab (Broad Institute / MIT) targeting graft-versus-host disease and other immunological conditions.

Academically, Couto holds an MSc in Biomedical Engineering (cum laude) from the University of Minho and a PhD in BioEngineering (summa cum laude) from Instituto Superior Técnico (IST-UTL) in Lisbon, completed in collaboration with MIT through the MIT-Portugal Program. Her combination of deep scientific training and hands-on company-building shapes her investment approach and her comfort operating at the earliest, most technical stages of biotech formation.

Investment Thesis & Focus

  • Invests at seed and Series A in European biotech and therapeutics, typically writing initial checks of ~€100K–€1M (sweet spot ~€500K) with substantial follow-on capacity from BGV's funds.
  • Backs companies with rigorous science and demonstrable proof of concept — she is known internally for leading scientific evaluation and due diligence, so validated data and mechanism matter more than narrative.
  • Focuses on therapeutics across oncology, CNS, rare/metabolic/autoimmune disease, and ophthalmology, reflecting BGV's disease-area orientation.
  • Comfortable co-creating and incubating companies from academic IP (e.g., Tessellate Bio's synthetic-lethality platform built around scientific founders' FANCM/ALT work), not just funding existing startups.
  • Values strong scientific founders and translational potential — her own path from academic bioengineering to operator to investor signals a preference for teams that can move science toward the clinic.

Notable Investments

  • Staten Biotechnology — Metabolic/ApoC-III-focused biotech where she was managing director (2015–2018); struck an argenX collaboration and a Novo Nordisk partnership with buy-out option reported at ~$485M.
  • Tessellate Bio — Oncology company built by BGV around a novel synthetic-lethality approach (FANCM / ALT), emerged from stealth Oct 2023 with an ~$8M seed; Couto was central to its creation and holds a board role.
  • Rhygaze (RhyGaze AG) — Basel-based optogenetic eye-therapy spinout; raised ~$11M seed (2024) and an ~$86M Series A (Jan 2025) with co-investors including GV (Google Ventures) and Novartis Venture Fund.
  • Cell2B — Cell-therapy company she co-founded and led as CEO (pre-BGV), based on Bhatia-lab (Broad/MIT) technology for GvHD and immunological diseases.
  • Broader BGV portfolio she is associated with includes companies such as Catalym, Complement Therapeutics, VectorY Therapeutics, Azafaros, and Kivu Bioscience (BGV notable exits include Acerta Pharma to AstraZeneca and Synaffix to Lonza).

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