
Declan Doogan
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- Full Name
- Dr. Declan Doogan, MD
- Title
- Co-Founder & Board Member (former Chief Medical Officer), Juvenescence
- Firm
- Juvenescence Ltd.
- Firm Type
- Longevity/biotech operating company & investor (he also invests as an angel/individual)
- Investment Stage
- Early stage / seed (founding and board-level biotech investments)
- Sector Focus
- Longevity, aging biology, and drug development — including fibrosis, cardiometabolic disease, neurodegeneration, inflammation, muscle wasting, and oncology
- Geographic Focus
- US and UK/Europe
- Location
- Toronto area, Canada (per +1 416 contact) / Isle of Man firm HQ
Background
Dr. Declan Doogan is a physician and pharmaceutical-industry veteran with more than 30 years of global drug-development experience. He earned his MD at the University of Glasgow, is a Fellow of the Royal College of Physicians and Surgeons of Glasgow, holds an honorary DSc from the University of Kent, and has served as a Visiting Professor at Glasgow University. His career is defined by senior R&D leadership rather than a traditional finance/VC path.
Doogan joined Pfizer in 1982 and spent much of his career there, rising to Senior Vice President and Head of Worldwide Development, with senior R&D roles across the US, UK, and Japan. He was the clinical development head for Zoloft (sertraline), and during his tenure leading worldwide development, multiple blockbuster programs — including Viagra, Lipitor, and Zoloft — were delivered under his leadership. He left Pfizer in 2007.
Post-Pfizer, Doogan moved into small-cap biotech leadership. At Amarin Corporation he served as Head of R&D and Interim CEO (October 2009–August 2010), where he helped raise roughly $100 million to fund a reorganization and portfolio realignment that led to the Phase III completion and NDA approval of Vascepa (icosapent ethyl) for elevated triglycerides.
In 2016 he co-founded Juvenescence with investor Jim Mellon and Greg Bailey, a longevity-focused biotech (HQ in Douglas, Isle of Man) building a pipeline and ecosystem of assets targeting aging and age-related disease, increasingly enabled by AI-driven drug discovery. He served as the company's Chief Medical Officer and remains a co-founder and board member. Alongside Juvenescence he has been a serial co-founder and board chairman across biotech, including Biohaven Pharmaceuticals (co-founder/chairman), Portage Biotech (CEO/chairman), and PHPrecisionmed.
Investment Thesis & Focus
- Invests at the intersection of longevity science and drug development — companies targeting the biology of aging and age-related disease, where his clinical/regulatory expertise adds value.
- Backs and builds companies primarily through founding and board roles rather than passive checks; he tends to get operationally involved as chairman, CEO, or CMO.
- Motivated by the conviction, in his own framing, that "we all can do better in managing health as we get older" — pairing therapeutics development with personal wellness practices (exercise, diet, supplementation).
- Sector breadth reflects Juvenescence's pipeline: fibrosis, cardiometabolic disease, neurodegeneration, inflammation, muscle wasting, plus oncology and precision medicine via his other ventures.
- Values rigorous, regulatory-credible science — his track record is built on shepherding assets through Phase III and NDA/FDA approval.
Notable Investments
- Juvenescence Ltd. — Co-founder (2016); longevity biotech developing an AI-enabled pipeline of anti-aging therapeutics.
- Biohaven Pharmaceuticals — Co-founder and chairman; neuroscience-focused company (best known for migraine drug Nurtec/rimegepant).
- Portage Biotech — CEO/chairman; immuno-oncology company (Nasdaq: PRTG).
- Amarin Corporation — Head of R&D / Interim CEO; led work culminating in Vascepa's NDA approval.
- Intensity Therapeutics (Nasdaq: INTS) — Board director; clinical-stage immuno-oncology.
- Tenax Therapeutics (Nasdaq: TENX) — Board director; cardiovascular/pulmonary therapeutics.
- Kleo Pharmaceuticals — Board director; immuno-oncology chemistry platform.
- BYOMass — Appointed to board of directors (2021); metabolic disease biotech.
- Causeway Therapeutics — Chairman; RNA-therapeutics for musculoskeletal disease.
- PHPrecisionmed — Co-founder/chairman; precision-medicine venture.
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