Kwasi Kyei
Principal
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- Full Name
- Kwasi Kyei
- Title
- Co-Founder & President (formerly Principal, Cigna Ventures)
- Firm
- Handspring Health (current) / Cigna Ventures (former)
- Firm Type
- Corporate venture capital (Cigna Ventures); healthcare startup operator (Handspring). Listed in stub as "Angel Investors."
- Investment Stage
- Late-venture / early-growth healthcare (at Cigna Ventures); seed-stage exposure as an angel/operator
- Sector Focus
- Healthcare, digital health, behavioral/mental health, health data
- Geographic Focus
- United States
- Location
- New York metro area
Background
Kwasi Kyei is a healthcare investor-turned-operator. He is Co-Founder and President (also described as COO) of Handspring Health, a virtual behavioral-health clinic for children, teenagers, and young adults that pairs evidence-based therapy with parent coaching and clinician training. He co-founded the company with Sahil Choudhry, a fellow Cigna Ventures alumnus, and the two launched it out of their shared healthcare venture-capital backgrounds.
Before founding Handspring, Kyei was a Principal at Cigna Ventures, the roughly $450M corporate venture arm of The Cigna Group, where he focused on late-venture and early-growth investments in healthcare. His deal work there included companies such as Datavant (health-data connectivity), Ginger (mental health, later merged with Headspace), Octave (behavioral health), and Cleerly Health (cardiac imaging/diagnostics).
Earlier in his career, Kyei worked as a healthcare investor at Sandbox Industries, in investment banking covering healthcare at UBS, and in corporate development and M&A at The Advisory Board Company. This blend of banking, corporate development, and venture experience underpins both his investing lens and his operating role.
Kyei earned a Bachelor's degree from Davidson College and an MBA from the Yale School of Management.
Investment Thesis & Focus
- Focused squarely on healthcare and digital health, reflecting a career spent entirely in the sector across banking, corporate development, and venture.
- At Cigna Ventures, invested at the late-venture / early-growth stage in companies advancing health-data infrastructure (Datavant), behavioral/mental health (Ginger, Octave), and clinical diagnostics (Cleerly).
- Strong affinity for mental and behavioral health — a thesis he ultimately backed with his own career by co-founding Handspring to fix the "missing middle" of youth mental healthcare with evidence-based, insurance-covered, virtual care.
- Values evidence-based clinical models and measurable outcomes (Handspring is built around clinician training, quality of care, and no-waitlist access), a signal of what he likely looks for in health companies.
Notable Investments
- Datavant — health-data connectivity and de-identification platform for securely exchanging healthcare data (Cigna Ventures portfolio).
- Ginger — on-demand mental health/coaching platform; merged with Headspace in 2021 to form Headspace Health (Cigna Ventures portfolio).
- Octave — modern behavioral-health/therapy provider (Cigna Ventures portfolio).
- Cleerly Health — AI-driven coronary artery disease diagnostics that quantify and characterize disease to tailor therapy (Cigna Ventures portfolio).
- Handspring Health — co-founder; virtual youth behavioral-health clinic (not a passive investment but his current venture).
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