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Mark Newhouse
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Mark Newhouse

General Partner

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At a glance

Full Name
Mark Newhouse
Title
General Partner
Firm
Innosphere Fund / Innosphere Ventures Fund
Firm Type
Early-stage venture capital fund
Investment Stage
Pre-seed, Seed, Series A
Check Size
Pre-seed investments up to $150,000 for incoming Innosphere client companies; Innosphere also leads larger seed rounds, including Epic River’s $1.75 million seed round and EyePop.ai’s $2.85 million round.
Target Company Profile
Science and technology-based startups, especially companies that have motivated founders, are likely to achieve a near-term corporate-acquisition exit, and can reach superior growth milestones with smaller amounts of capital.
Sector Focus
B2B SaaS software, Cleantech, Medtech; earlier Innosphere materials also cite bioscience, life sciences, hardware, IoT, water, energy, transportation, and advanced materials.
Geographic Focus
Mid-America Mountain Plains region, with historical emphasis on Colorado-based Innosphere client companies.
Location
Denver / Fort Collins, Colorado

Background

Mark Newhouse is a General Partner at Innosphere Fund, an early-stage venture fund associated with Innosphere’s long-running technology incubator and commercialization platform. In 2017, he was named a General Partner of the fund; at the time, he said he joined because Innosphere was “really focused on company success” and had “a positive and substantive impact” on its companies.

Before investing, Newhouse spent much of his career at Corning, where he worked in telecommunications, consumer electronics, and cleantech markets. The National Center for Family Philanthropy says he helped deliver products and businesses generating more than $2.0 billion in revenue, co-invented LEAF fiber with Yanming Liu, founded and led a Corning optical-switching division, and completed his Corning tenure in Shanghai as a Senior Vice President of Corning Incorporated.

Since moving to Colorado, Newhouse has invested in and advised startups and served on boards including SWIR Vision Systems, Epic River, and Boulder AI. He is also active in impact investing and philanthropy: he co-founded the Left Behind Workers Fund, co-founded AidKit, founded the Social Venture Partners Impact Investing Group, and has served on boards including The Denver Foundation and Impact Charitable.

Investment Thesis & Focus

  • Innosphere says it invests in “entrepreneurs that are building technology-that-matters in markets-that-matter.”
  • The firm focuses on enterprise B2B SaaS software, Cleantech, and Medtech at Pre-seed, Seed, and Series A.
  • Innosphere’s stated model is to “get involved early,” work with companies that may be “rough around the edges,” and help with practical company-building needs including hiring, product development, sales, marketing, customer success, UX, finance, and HR.
  • The fund seeks companies with motivated founders that can achieve meaningful growth milestones with smaller amounts of capital and have a plausible path to corporate acquisition or PE buyout.
  • Newhouse’s own comments on Boulder AI show a preference for differentiated products, experienced teams, customer validation, and large market opportunity: he cited the company’s product as “uniquely capable,” with “an experienced team” and “a rapidly growing opportunity.”
  • In his philanthropic impact investing, Newhouse has emphasized measurable outcomes, saying the pay-for-success model lets donors give “only when impact is achieved.”

Notable Investments

  • Epic River - Financial-technology and secure document workflow software provider for banks and credit unions; Innosphere led its $1.75 million seed round, and Kinective acquired Epic River on May 6, 2025.
  • Boulder AI - Privacy-focused AI camera and edge-computing company; Innosphere made a seed investment in 2019, and Newhouse served on its board.
  • SWIR Vision Systems - Short-wave infrared imaging technology company; Newhouse is listed as a director in SEC-related filings.
  • EyePop.ai - Self-service AI computer vision platform; Innosphere led a $2.85 million investment round announced February 25, 2025.
  • Aspero Medical - GI endoscopy medical-device company based on University of Colorado technology; Innosphere provided initial equity funding and later seed support.
  • ResourceX - Public-sector priority-based budgeting software company; listed as an Innosphere portfolio exit and acquired by Tyler Technologies in 2023.
  • Nickelytics - Out-of-home advertising technology platform; Innosphere announced an investment in June 2024.
  • VirtualZ Computing - Mainframe and hybrid-cloud data access software company; listed in Innosphere portfolio materials as active B2B SaaS.

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