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Peter Embi
ResearchedAngel Investors

Peter Embi

Chief Executive Officer & President of Board

Angel InvestorsSeed Round
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At a glance

Full Name
Peter J. Embí, MD, MS, FACP, FACMI, FAMIA, FIAHSI
Title
Professor of Biomedical Informatics & Medicine, Vanderbilt University Medical Center; co-Director, ADVANCE AI Center (former President & CEO, Regenstrief Institute; co-founder/CMO, Signet Accel)
Firm
Vanderbilt University Medical Center (academic); Signet Accel (startup co-founder)
Firm Type
Physician-scientist / academic entrepreneur and startup co-founder (the "Angel Investor / Seed" label in the source database reflects his early-stage health-IT founding and advisory activity, not a formal investment fund)
Investment Stage
Early-stage / seed-stage health IT and clinical-informatics ventures
Check Size
Not publicly disclosed
Target Company Profile
Founder-led health IT and clinical/translational informatics startups, often academic spinouts
Sector Focus
Biomedical & clinical-research informatics, health data interoperability, learning health systems, AI/ML in healthcare
Geographic Focus
United States (Nashville, TN; Indianapolis, IN; Midwest/Southeast academic medicine hubs)
Location
Nashville, Tennessee (Vanderbilt University Medical Center, 2525 West End Avenue)

Background

Peter J. Embí is an internationally recognized physician-scientist, educator, and leader in biomedical and clinical-research informatics. He is widely credited as a founder of the clinical research informatics field, created the nation's first Chief Research Information Officer (CRIO) role, and originated the concept of "algorithmovigilance" for monitoring AI in healthcare. He is an elected member of the National Academy of Medicine and holds fellowships in the American College of Physicians (FACP), the American College of Medical Informatics (FACMI), AMIA (FAMIA), and the International Academy of Health Sciences Informatics (FIAHSI). He has authored more than 160 peer-reviewed articles, abstracts, books, and book chapters.

His academic career began at the University of Cincinnati College of Medicine, where he was founding director of the UC Center for Health Informatics and led informatics for the Cincinnati Center for Clinical and Translational Science and Training. He then moved to The Ohio State University, where he served as professor and vice-chair, assistant dean, and Chief Research Information Officer — and where, in 2014, he co-founded the data-integration startup Signet Accel, creator of the federated platform Avec®.

In October 2016 he was named President and CEO of the Regenstrief Institute in Indianapolis, a role he held from 2016 to 2021, concurrent with appointments as Professor and Associate Dean for Informatics and Health Services Research at the Indiana University School of Medicine and VP for Learning Health Systems at IU Health. During his tenure he oversaw a roughly 50% increase in funded research and expanded the institute's national and international reach.

Effective January 1, 2022, Embí joined Vanderbilt University Medical Center as Chair of the Department of Biomedical Informatics (DBMI) and Senior Vice President for Research and Innovation. He stepped down from those leadership roles on May 1, 2025, remaining as a senior faculty member and co-Director of the DBMI ADVANCE AI Center. He is a past President and Board Chair of AMIA and current President of the American College of Medical Informatics, and serves on national bodies including the NIH National Library of Medicine Board of Scientific Counselors and AHRQ's National Advisory Council.

Investment Thesis & Focus

  • Backs and builds at the intersection of clinical/biomedical informatics, health data interoperability, learning health systems, and AI/ML in medicine — the domains where he is an academic authority.
  • His "investing" is primarily as an academic entrepreneur: co-inventing and co-founding health-IT startups, partnering with companies to create and evaluate innovations, and building programs that help faculty translate discoveries into practice.
  • Strong bias toward rigorously evaluated, evidence-based health IT — he champions "algorithmovigilance" (ongoing surveillance of deployed clinical algorithms), signaling a preference for ventures that take safety, validation, and real-world evidence seriously.
  • Values federated, interoperable data infrastructure (the thesis behind Signet Accel's Avec® platform) that enables multi-institution research and translational medicine.

Notable Investments

  • Signet Accel, LLC — Co-founder and Chief Medical Officer; creator of its flagship federated data-integration platform Avec®. Spun out of an Ohio State licensing agreement (reported $275K upfront license, 2014) to bring interoperability to healthcare data and speed translational research.
  • Indiana Health Information Exchange (IHIE) — Served as a Director on the Board, supporting one of the nation's largest health information exchanges (during his Regenstrief/Indiana tenure).
  • Broader portfolio of co-invented and co-founded health IT startups and industry research partnerships (specific names/rounds not publicly itemized).

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