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Todd Pietri
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Todd Pietri

Managing Partner

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At a glance

Full Name
Todd T. Pietri
Title
Managing Partner & Co-Founder
Firm
Activate Venture Partners (formerly Milestone Venture Partners)
Firm Type
Early-stage venture capital firm (functions as first-round / seed-stage investor; often characterized as angel/seed)
Investment Stage
Seed and early Series A
Check Size
Up to ~$5 million for first-round financing (aggregators cite a range of roughly $100K–$5M)
Target Company Profile
Capital-efficient, customer-driven companies led by visionary founders with deep domain knowledge and operational scaling ability, in markets hitting a demand inflection point
Sector Focus
Tech-enabled healthcare / digital health, plus software, data, and applied/tech-enabled services
Geographic Focus
United States (primarily East Coast / NY metro and Mid-Atlantic)
Location
New York, NY (595 Madison Avenue); firm also has an office in Bethlehem, PA

Background

Todd Pietri is a Managing Partner and co-founder of Activate Venture Partners, an early-stage venture firm focused on tech-enabled healthcare and applied technology. He has worked as a venture capitalist for more than 20 years, participating in over 50 equity financings and serving as a director or board observer for more than 30 companies. In 1999 he co-founded Milestone Venture Partners alongside Ed Goodman; Milestone was later reconstituted/rebranded as Activate Venture Partners (founded 2017), of which Pietri and the predecessor funds are the antecedents. Across these vehicles he has originated and/or led dozens of investments in software, data, and tech-enabled services businesses, the majority in the digital health sector, where he has built a network of founder relationships.

Before venture capital, Todd was co-head of the Technology and Communications Investment Banking Group at Legacy Securities and a member of Legacy's direct investment team, which provided mezzanine and growth equity through its affiliate Legacy Capital Partners. Earlier in his career he was an associate at a middle-market private equity firm (Callier Interest) and held IT consulting and direct-sales roles at an ERP software firm (CompuSystems).

He holds a BA, cum laude, in English from Duke University and an MBA from the Robinson School of Business at Georgia State University, where he graduated first in his class. He is also a CFP charterholder. He has served as an advisory board member for the Healthcare Advisory Board of the Partnership for New York City.

Investment Thesis & Focus

  • Backs "visionary founders with domain knowledge and the ability to scale a business operationally," targeting markets experiencing a demand inflection point where a new approach can disrupt the status quo.
  • Positions the firm as "first round investors for customer-driven entrepreneurs" — i.e., leading or anchoring the earliest institutional round.
  • Writes first-round checks of roughly $5 million or less into capital-efficient businesses.
  • Primary sector emphasis is tech-enabled healthcare / digital health (50+ healthcare companies across a portfolio of 100+ investments), with adjacent focus on software, data, and tech-enabled services.
  • Emphasizes hands-on partnership: Pietri "has developed significant expertise and valuable relationships among digital health founders, providing valuable resources to entrepreneurs."

Notable Investments

  • Tabula Rasa HealthCare — medication risk-management / pharmacy tech company; a Milestone/Activate portfolio company that went public (IPO 2016).
  • Medidata Solutions — clinical-trial software platform; went public and was later acquired by Dassault Systèmes.
  • Diameter Health — clinical-data normalization / interoperability company; acquired by Availity (2022).
  • Healthify — social-determinants-of-health / community resource network; acquired by WellSky (2021).
  • Sapphire Digital — healthcare navigation / cost-transparency platform.
  • Princeton Identity — biometric identity (iris/facial) technology spun out of SRI.
  • SkillSurvey — reference-checking and talent-intelligence SaaS.
  • FSA Store / Benefix / RideHealth / CrowdHealth / KAID Health / Cypris — tech-enabled healthcare, benefits, and health-data companies in the firm's portfolio.

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